VIMPAT
Generic Name/API: lacosamide
Manufacturer: Aesica Pharmaceuticals GmbH
Dosage Forms & Strength & Pack Size:
Vimpat is available in packs of 14, 28, 56, 60, 14 x 1 and 56 x 1 film-coated tablets.
Vimpat 50 mg and Vimpat 100 mg are available in packs of 168 film-coated tablets and Vimpat 150 mg and Vimpat 200 mg are available in multipacks comprising 3 cartons, each containing 56 tablets. The 14 x 1 and 56 x 1 film-coated tablets packs are available as perforated unit dose PVC/PVDC blisters sealed with an aluminium foil, the 14, 28, 56 and 168 packs are available with standard PVC/PVDC blisters sealed with an aluminium foil, the 60 packs are available in HDPE bottles with a child-resistant closure. Not all pack sizes may be marketed.
Storage:
Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F to 86°F) [see USP Controlled Room Temperature].
Vimpat is indicated as monotherapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 2 years of age with epilepsy.
Vimpat is indicated as adjunctive therapy
• in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 2 years of age with epilepsy.
• in the treatment of primary generalised tonic-clonic seizures in adults, adolescents and children from 4 years of age with idiopathic generalised epilepsy.
Warnings and precautions
Talk to your doctor before taking Vimpat if:
• you have thoughts of harming or killing yourself. A small number of people being treated with
antiepileptic medicinal products such as lacosamide have had thoughts of harming or killing
themselves. If you have any of these thoughts at any time, tell your doctor straight away.
• you have a heart problem that affects the beat of your heart and you often have a particulary
slow, fast or irregular heart beat (such as AV block, atrial fibrillation or atrial flutter).
• you have severe heart disease such as heart failure or have had a heart attack.
• you are often dizzy or fall over. Vimpat may make you dizzy – this could increase the risk of
accidental injury or a fall. This means that you should take care until you are used to the
effects of this medicine.
If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking
Vimpat.
If you are taking Vimpat, talk to your doctor if you are experiencing a new type of seizure or
worsening of existing seizures.
If you are taking Vimpat and you are experiencing symptoms of abnormal heartbeat (such as slow,
rapid or irregular heartbeat, palpitations, shortness of breath, feeling lightheaded, fainting), seek
medical advice immediately (see section 4).
Children
Vimpat is not recommended for children aged under 2 years with epilepsy characterised by the
occurrence of partial-onset seizure and not recommended for children aged under 4 years with primary
generalised tonic-clonic seizures. This is because we do not yet know whether it will work and
whether it is safe for children in this age group.
Other medicines and Vimpat
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other
medicines.
In particular, tell your doctor or pharmacist if you are taking any of the following medicines that affect
your heart – this is because Vimpat can also affect your heart:
• medicines to treat heart problems;
• medicines which can increase the “PR interval” on a scan of the heart (ECG or
electrocardiogram) such as medicines for epilepsy or pain called carbamazepine, lamotrigine
or pregabalin;
• medicines used to treat certain types of irregular heart beat or heart failure.
If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking
Vimpat.
Also tell your doctor or pharmacist if you are taking any of the following medicines – this is because
they may increase or decrease the effect of Vimpat on your body:
• medicines for fungal infections such as fluconazole, itraconazole or ketoconazole;
• medicines for HIV such as ritonavir;
• medicines for bacterial infections such as clarithromycin or rifampicin;
• a herbal medicine used to treat mild anxiety and depression called St. John’s wort.
If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking
Vimpat.
Vimpat with alcohol
As a safety precaution do not take Vimpat with alcohol.
Pregnancy and breast-feeding
Fertile women should discuss the use of contraceptives with the doctor.
*The contents of this site are for reference only. We do not offer drug procurement service. All information must not be used for any commercial purpose.
